Modified hartwig and siegel scale pdf

Modified hartwig and siegel scale pdf

Modified hartwig and siegel scale pdf
Severity of the reaction was assessed by using the Modified Hartwig and Siegel Severity assessment scale [5] and the severity is broadly categorized in to “mild”, “ moderate” and “severe” for each ADR.
Modified Hartwig and Siegel scale of severity assessment showed that most of the reactions were of “mild level 1” severity except for vomiting, diarrhea and hypocalcaemia, which were of “moderate level 3” severity. Conclusion : Cisplatin-based chemotherapy has a high potential to cause adverse effects. Most of the reactions were of milder nature but not preventable. The common adverse
Severity of the suspected ADRs assessed using Modified Hartwig and Siegel Scale, revealed that 2(4.5%) suspected ADRs were severe, 27 (61.4%) ADRs …
modified Hartwig and Siegel scale. Results: A total of 100 ADRs of different types were observed in 77 patients out of total 177 patients included in our study, with an overall prevalence of about 43.5%.
per Naranjo scale and modified Hartwig and Siegel scale respectively. Result: In this study, Out of 263 patient enrolled on DOTS therapy, n= 74(28.14%) patients developed ADRs in which male patient were n= 48 (27.58%) and female patient were n= 26 (29.21%). Total no. of ADRs reported in n=74 patients were n=212. The severity of ADRs were from mild group with n= 161(75.94%) followed by …
was evaluated using the Modified Hartwig and Siegel scale, based on which it was categorized as moderate (Level 4(a)) reaction. Case 3 An 80-year-old male patient, with body mass index of 35 kg/m2, was admitted to the internal medicine unit of a tertiary care hospital with complains of breathlessness and cough with expectoration since three days. He also had complains of orthopnea. He was a
Majority of the reactions were mild as per Modified Hartwig and Siegel scale and the same was observed in studies by Thiesen et al., but varied from the results by Oshikoya et al. . Antibiotics contributed to most of the reactions and there was no change in suspected drug nor additional treatment was given since major share of the reactions were mild.

based on modified Hartwig and Siegel severity scale. In 76.59% of the reports, the reaction was considered to be In 76.59% of the reports, the reaction was considered to be preventable based on Schumock and Thornton preventability scale.
ADR,8 assessment of severity per Modified Hartwig and Siegel Scale, 9,10 its seriousness, to determine preventability using Criteria of Schumock and Thornton. 11,12 Causality
Modified Hartwig and Siegel scale, “80%” of ADRs shown by 5FU-Cis were moderately severe. Based Based on Modified Schumock & Thornton Preventability scale, 5FU …
the Modified and Siegel scale (Ta ble3). Most of the ADRs were mild (10 1) (73.1% ), 28(20.28% ), were moderate and only a few9 (6.3% ) were severe. In this study, ADRs were assessed based on Naranjo’s Casuality assessment scale. Most of the reported ADRs were possible-119(86.23 %) and some were probable-19(13.76% ) (Ta ble 4). From this study it was found that there was a recovery …
Algorithm scale, modified Hartwig and Siegel scale and modified Shumock and Thornton scale are important tool to assess causality, severity and preventability respectively 6-8 .
modified Hartwig and Siegel’s scale, which classifies severity of ADR as mild, moderate or severe based on factors like necessity of change in treatment, increased duration of hospital stay and disability produced by ADR. • Modified Schomock and Thronton preventability assessment Assessment of preventability was done by modified Schomock and Thronton scale. According to this scale …
The modified Hartwig and Siegel scale classifies severity of ADR as mild, moderate or severe with various levels according to factors like requirements for change in treatment, duration of hospital stay, and the disability produced by the Adverse Drug Reaction.
preventability by Modified Schumock & Thornton scale and severity using Hartwig and Siegel Scale. Predictability Predictability was categorized as Type A and Type B ADRs.
I Abstract Adverse Drug Reactions (ADRs) are a global health problem and a leading cause of death, illness and injury in economically developed countries.
The modified Hartwig and Siegel scale classifies severity as “mild”, “moderate”, and “severe”. Paramjeet Singh et al JMSCR Volume 04 Issue 08 August Page 12118

(PDF) Preventability and Severity Assessment in Reporting


Reporting Adverse Drug Reactions Among Hospitalized

Using both the WHO causality assessment scale and the Naranjo scale [15, 16], the ADRs were categorized as probable, while based on the modified Hartwig and Siegel scale of severity assessment, the reactions were categorized as ‘mild level 1’ severity.
Self-Medication Practices with Antibiotics among Second Year Medical Students of Government Medical College, Raigarh, Chhattisgarh; A Study on Siddha Urinary Diagnostic Methodology Neerkkuri and Neikkuri in Adhiratha Azhutham (Hypertension)
Modified Hartwig and Siegel scale showed most reactions (41.4%) to be of moderate level 4(a) severity, while 30.6% of reactions were of mild level 1 severity. About 30.8% of the ADRs were definitely preventable according to the modified Schumock and Thornton scale. Conclusion: ADRs are most important causes of morbidity and mortality and increase the economic burden on patient and …
modified Schumock and Thornton scale, modified Hartwig and Siegel scale, respectively. Incidence rate, Incidence rate, relative risk and attributable risk were evaluated among the regimens.
assessment, WHO Probability Scale. The severities of ADRs were assessed by ADR Severity assessment Scale (Modified Hartwig and Siegel). Analyzed the prescribing pattern of Corticosteroids in various departments (Drugs, Dose, Route, and Frequency). Also found out the incidence of interaction of corticosteroids with other drugs. Result analysis The causality assessments of suspected ADRs …
Overall, the severity assessment of ADRs using Modified Hartwig and Siegel scale found that most of the ADRs belonged to the moderate (68.6%), followed by mild (21.6%) and severe (9.8%) category. Similar findings were reported by Emma and colleagues from the United Kingdom among 3695 hospitalized inpatients [ 6 ].
Severity of ADR (assessed by Modified Hartwig and Siegel Scale) [22].Examples of ADRs assessed as severe are those that caused death, directly life-threatening, lengthened hospitalization or shift to a
Severity of the reaction was assessed using ADR Severity Assessment Scale (Modified Hartwig and Siegel) – which classifies ADR into mild, moderate and severe. Preventability assessment was done by using Schumock and Thornton scale [ 9 ] which classifies the ADRs into definitely preventable, probably preventable and not preventable.
ADRs were analyzed by using the modified Hartwig Siegel’s severity assessment scale and the modified Schumock and Thornton scale, respec-tively [Naranjo et al. 1981;
The severity of ADRs was assessed using modified Hartwig and Siegel scale into mild, moderate, and severe (level 1–7). Direct cost was calculated, documented, and subjected for analysis. Direct cost was calculated, documented, and subjected for analysis.


ADRs was assessed by Modified Hartwig and Siegel Scale 23 which gives an overview of the severity of ADR whether it is mild, moderate, or severe in nature. Thus the present study was undertaken: 24 1. To collect the demographic details of the paediatric populations showing atleast one ADR . Available online at www.ijpras.com
Modified Hartwig and Siegel scale showed most reactions (41.4%) to be of “moderate level 4(a)” severity, while 30.6% of reactions were of “mild level 1” severity. About 30.8% of the ADRs were “definitely preventable” according to the modified Schumock and Thornton scale.
Dhanalakshmi and Harikrishnan, IJPSR, 2017; Vol. 8(10): 4396-4401. E-ISSN: 0975-8232; P-ISSN: 2320-5148 International Journal of Pharmaceutical Sciences and Research 4397
Pattern of Adverse Drug Reactions of Various Chemotherapeutic Agents in Cancer Patients in Kumaun Region Authors Gaur S1, Sinha A.K2, The modified Hartwig and Siegel scale classifies severity as “mild”, “moderate”, and “severe”. The data collected, analyzed using Microsoft excel and frequency and percentage were determined for each variable. Result In the present study 187 ADRs
Causality, severity, and preventability assessments were done by using Naranjo’s scale, modified Hartwig and Siegel’s scale, and modified Schumock and Thornton Scale, respectively. Data were expressed in proportions. Frequency of ADRs in therapeutic and prophylactic groups were compared with phase III trial of oseltamivir by using Chi-square test.
Modified Hartwig and Siegel scale showed most reactions (41.4%) to be of “moderate level 4(a)” severity, while 30.6% of reactions were of “mild level 1” severity. About 30.8% of the ADRs were “definitely preventable” according to the modified Schumock and Thornton scale. Conclusion: ADRs are most important causes of morbidity and mortality and increase the economic burden on patient and
Adverse drug reaction documentation form, Wills and Brown classification, Causality assessment scale (Naranjo’s scale), Modified Hartwig and Siegel severity scale, Schumock and Thornton preventability scale, ADR alert card and thank you note were the various tools utilized for the conduct of study.
The modified Hartwig and Siegel scale classifies severity of ADR as mild, moderate or severe with various levels according to factors like requirement for change in treatment, duration of hospital stay and


The severity of reported reactions was assessed by using Modified Hartwig and Siegel Scale and Received: 28 July 2013 Preventability of the ADRs was assessed by Modified Schumock and Thornton Revised: 16 January 2014 Scale. Accepted: 17 January 2014 Results: Patients aged between 5 to 12 years and with a male preponderance of 3:2. The offending NSAID was ibuprofen for 8 of the patients
National formulary (BNF) 5 2012 and severity assessed via Modified Hartwig and Siegel Scale. The survey was conducted in accordance with the Principles of
Each reported case of zidovudine and stavudine induced anemia was assessed for its causality by using the WHO probability scale and also with Naranjo’s algorithm. Preventability was assessed using Schumock and Thornton criteria and severity was assessed using the modified Hartwig and Siegel scale. Multivariate logistic regression was used to evaluate the influence of zidovudine induced
the Modified Hartwig and Siegel severity criteria, majority of the reactions were of moderate level 4 (a) severity (Table 4). According According to the categorization of the reactions based on Wills and Brown classification, about 78.1% ADRs were type A, 2.4% were type B,
for their severity using Modified Hartwig and Siegel scale.[8] Tools in the Study Modified Hartwig and Siegel scale.[8] Hartwig et al. categorized ADRs into seven levels as per their severity level 1 and 2 fall under mild category, level 3 and 4 under moderate, and level 5, 6, and 7 fall under category severe. Mild Level 1: An ADR occurred but required no change in treatment with the suspected

Drug Utilization Evaluation of Corticosteroids Based on

probability scale and modified Hartwig scale respectively.12, 13 RESULTS A total of 295 patients, 218 men and 87 women using drugs for central nervous system related disorders were entered the study, among them 157 patients 108 men and 49 women were experienced 199 adverse drug reactions (Table 1). Upon age distribution of ADRs in patients, adult patients experienced 58.58% of ADRS followed …
Schumock and Thornton scale and modified Hartwig and Siegel scale respectively. Results: A total of 70 patients were included in the study. Cyclophosphamide was the most commonly used chemotherapeutic
The results were compared with British National formulary (BNF)5 2012 and severity assessed via Modified Hartwig and Siegel Scale. The survey was conducted in accordance with the Principles of declaration of Helsinki. The inclusion criteria consisted of female patients receiving AC combination therapy for breast cancer treatment (Adjuvant curative protocol) aged above 18 years. Exclusion
the Modified Hartwig and Siegel scale. The severity assessment of ADRs showed that 51% reactions were moderate and 49% were of the ‘mild’ nature as per the Hartwig et al scale. DISCUSSION Out of 91 patients enrolled in the study, 15 patients developed 19 ADRs (20.87%). The highest numbers of ADRs [15 (78.94%)] were observed in males which is in contrast to the study by Yee & Shakya et al12
Severity(Modified Hartwig and Siegel scale)[8],Preventability(Schumock and Thornton scale)[9].All the adverse drug reactions occurred were documented in Central Drugs Standard Control Organization(CDSCO) ADR form and
Severity Assessment by Modified Hartwig and Siegel Scale showed that 56.31 (58) ADRs were moderate, % 38.83 % (40) ADRs weremild and 4.85% (5) ADRs were severe.
Schumock and Thornton, modified Hartwig’s and Siegel scale and Naranjo’s algorithm were used to evaluate severity, causality and preventability. Inclusion and Exclusion Criteria Only those participants were recruited who were willing to continue with the study and were cases of breast carcinoma that were being treated at KIRAN hospital, Karachi. It was required for ease of follow-up of the
31/12/2012 · Severity assessment of ADRs: ADR severity assessment scale (Modified Hartwig and Siegel) Mild. Level 1: The ADR requires no change in treatment with the suspected drug. OR. Level 2: The ADR requires that the suspected drug be withheld, discontinued or otherwise changed. No antidote or other treatment is required, and there is no increase in lenght of stay. Moderate . Level 3: …
per modified Hartwig and Siegel scale and Modified Shumock and Thorton scale respectively. The causality was assessed using the Naranjo’s Causality Assessment Scale. Abstract Adverse Drug Reactions (ADRs) are inevitable risk factors associated with cancer chemotherapy. A great emphasis is needed for their detection, assessment, monitoring, reporting and prevention. A prospective cohort …

Causality Severity and Preventability Assessment of

The modified Hartwig and Siegel scale classifies severity of ADR as mild, moderate or severe with various levels according to factors like requirement for change in treatment, duration of hospital stay, and the disability produced by the adverse drug reaction.
Preventability was assessed using Schumock and Thornton criteria and severity was assessed using modified Hartwig and Siegel scale. Bivariate analysis and subsequently multivariate logistic regression were used to identify the risk factors for ADRs. Data from spontaneous reporting was assessed using Bayesian neural network method for possible ADR signals.
Each reported ADR was assessed for its causality by using various scales, namely the WHO probability scale, Naranjo’s scale. The The severity of each reported ADR was assessed using the criterion developed by modified Hartwig et al., and Siegel scale.
the modified Hartwig and Siegel scale.13 Mild Level 1: The ADR requires no change in treatment with the suspected drug. Level 2: The ADR requires that the suspected drug be withheld, discontinued or otherwise changed. No antidote or other treatment is required, and there is no increase in length of stay. Moderate Level 3: The ADR requires that the suspected drug be withheld, discontinued or
trial as any investigation in human subjects indented to is of paramount importance in clinical research process. provide investigators in clinical trials to.
By using modified Hartwig and Siegel scale the severity of the reaction was found to be moderate [4]. DISCUSSION Amongst the 5HT 3 receptor antagonists, ondansetron is widely used in paediatric age group for the treatment of nausea and vomiting due to gastroenteritis. It
Severity of the ADR were assessed using modified hartwig and siegel scale. Among 97 ADRs in 120 patients about 94 ADRs fall under level 1 and 2 ADR under level 2 and 1 ADR at level 3.When clubbed both level 1 and level 2 belonged to mild category and level 3 belonged to moderate category. DISCUSSION The present study has reported the incidence and attempted to profile suspected …
assessed using the modified Hartwig and Siegel scale.11 If the drug had previously been well tolerated by the patient at the same dose and route of administration, the ADR was considered as ‘not predictable’. If there was a history of allergy or reactions to the drug during previous exposure, the ADR was considered ‘predictable’. In patients who had never received the drug previously

Department of Pharmacology Government Medical College


Comparative survival and safety analysis of cisplatin

was assessed by Modified Hartwig and Siegel Scale [26]. Preventability was assessed by Modified Schumock Preventability was assessed by Modified Schumock and Thornton Scale[27][28].
three scales employed for ADRs assessment {i.e. (WHO) causality assessment scale, Naranjo’s Algorithm and modified Hartwig’s and Siegel scale for preventability and severity of ADRs}, the
Evaluation of Adverse Drug Reactions in teaching hospital in Kumoun Region Authors Gaur S1, The modified Hartwig and Siegel scale classifies severity as “mild”, “moderate”, and “severe”. The data collected, was analyzed using Microsoft excel and frequency and percentage were determined for each variable. Result 265 ADRs form were received from Dr. Sushila Tiwari Memorial
Modified Hartwig & Siegel Severity Assessment Scale 1992 was used to assess severity of ADRs found. Results: In this study, 150 patients were enrolled, out of that 10
15/12/2013 · Severity of the reaction was assessed using ADR Severity Assessment Scale (Modified Hartwig and Siegel) – which classifies ADR into mild, moderate and severe. Preventability assessment was done by using Schumock and Thornton scale [ 9 ] which classifies the ADRs into definitely preventable, probably preventable and not preventable.
excel 2007 spreadsheet along with Naranjo Algorithm for causality assessment and Modified Hartwig and Siegel scale for determining severity. Results: Total MDR patients (366) under MDR-TB treatment in Nepal through DOTS PLUS were
ADRs, preventability was assessed by using modified Schumock and Thornton scale, causality was assessed by WHO probability scale and severity was assessed by using modified Hartwig and Siegel Scale. Results : A total of 1120
Severity of ADRs – using Modified Hartwig and Siegel Scale Organ system involved – using World Health Organization – Adverse Reaction Terminology (WHO-ART) system organ class sorting Class of drugs implicated The evaluations of the ADRs were carried out by one of the authors who had an experience in the field of Pharmacovigilance. Subsequently, the comparison of the causality of the …
Modified Hartwig and Siegel scale showed most reactions (41.4%) to be of “moderate level 4(a)” severity, while 30.6% of reactions were of “mild level 1” severity. About 30.8% of the ADRs were “definitely preventable” according to the modified Schumock and Thornton scale. Conclusion: ADRs are most important causes of morbidity and mortality and increase the economic burden on

Pharmacovigilance Study of Adverse Cutaneous Drug


Study of prescription pattern and adverse drug reactions

PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS: A CASE REPORT Archana Vijayendra1, Nilay Modi 2, Kesha Vaidya , Rima Shah 3, Sagun Desai 1
Results confirm that the chronic obstructive pulmonary disease is a disease with high appearance of adverse drug reactions, and causes many additional costs to the healthcare system.
When the ADRs were assessed for severity by using modified Hartwig and Siegel’s severity scale, 73.42% (105/143) of the ADRs were assessed to be moderately severe [Table 6].
Severity assessment was done by modified Hartwig and Siegel’s scale[18], which classifies severity of ADR as mild, moderate or severe based on factors like necessity of change in treatment, increased duration of hospital stay and disability produced by ADR. Assessment of preventability was done by modified Schomock

Adverse Drug Reactions in Rheumatoid Arthritis Patients

scale and severity assessed by using modified Hartwig and Siegel scale. The management of reported ADRs and the outcome of the management of ADRs were determined. Results:
15 Severity of the reaction was assessed using the Modified Hartwig and Siegel scale which classifies ADR into mild, moderate and severe. 16 Preventability assessment was done by using Schumock
adverse drug reaction-causality assessment Srinivasan R* and Ramya G PES College of Pharmacy, Department of Pharmacy Practice, 50 Ft. Road, Hanumanth Nager,

INCIDENCE OF ADVERSE DRUG REACTIONS IN THE INPATIENT

A Cross-sectional Observational Study to Evaluate

Whiplash Rove Beetle Dermatitis Among Students at


Effects of Chemotherapy in Breast Cancer Patients

Adverse drug reactions to antiretroviral therapy (ART) an

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assessed using the modified Hartwig and Siegel scale.11 If the drug had previously been well tolerated by the patient at the same dose and route of administration, the ADR was considered as ‘not predictable’. If there was a history of allergy or reactions to the drug during previous exposure, the ADR was considered ‘predictable’. In patients who had never received the drug previously

Notes on Clinical Pharmacology Severity Assessment of ADRs

The modified Hartwig and Siegel scale classifies severity of ADR as mild, moderate or severe with various levels according to factors like requirements for change in treatment, duration of hospital stay, and the disability produced by the Adverse Drug Reaction.

A survey on gastrointestinal adverse drug reactions of
Pharmacy Free Full-Text Study on the Classification

I Abstract Adverse Drug Reactions (ADRs) are a global health problem and a leading cause of death, illness and injury in economically developed countries.

Adverse Drug Reactions in Rheumatoid Arthritis Patients

Modified Hartwig and Siegel scale of severity assessment showed that most of the reactions were of “mild level 1” severity except for vomiting, diarrhea and hypocalcaemia, which were of “moderate level 3” severity. Conclusion : Cisplatin-based chemotherapy has a high potential to cause adverse effects. Most of the reactions were of milder nature but not preventable. The common adverse

Whiplash Rove Beetle Dermatitis Among Students at

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